Chen Li*,Lin Xiaojie..Clinical effect and mechanism of compound herba houttuyniae mixture for the childern with macrolide-resistant myeoplasma pneumoniae [J].,2018,40(8):715-718.[doi:10.3760/cma.j.issn.1673-4246.2018.08.008]
复方鱼腥草合剂联合阿奇霉素干混悬剂治疗儿童耐药肺炎支原体肺炎临床研究
- Title:
- Clinical effect and mechanism of compound herba houttuyniae mixture for the childern with macrolide-resistant myeoplasma pneumoniae
- Keywords:
- Pneumonia; Mycoplasma; Child; Macrolides; Drug resistance; Compound herba houttuyniae mixture; Integrated Chinese traditional and western medicine therapy
- 摘要:
- 目的 评价复方鱼腥草合剂联合阿奇霉素干混悬剂治疗儿童耐药肺炎支原体肺炎(macrolide-resistant myeoplasma pneumoniae, MRMPP)的疗效。方法 将符合入选标准60例MRMPP患儿采用随机按数字表法分为2组，每组30例。对照组口服阿奇霉素干混悬剂，治疗组在对照组基础上加用复方鱼腥草合剂。2组均治疗21 d。采用ELISA法检测血清MP-IgM、IL-6、IL-10、IL-17水平，观察患儿治疗期间体温异常时间和咳嗽持续时间，记录不良反应。结果 治疗组总有效率为86.7%(26/30)，对照组为56.7%(17/30)，2组比较差异有统计学意义(χ2＝5.253，P＝0.022)。治疗组体温异常时间[(1.2±0.3)d比(3.7±2.2)d，t＝6.293]、咳嗽持续时间[(7.5±2.3)d比(14.9±3.7)d，t＝9.232]均较对照组缩短(P＜0.01)。治疗后，治疗组血清IL-6[(14.69±8.26)pg/ml比(8.41±5.26)pg/ml，t＝3.512]、IL-17[(5.61±2.77) pg/ml比(2.09±1.53)pg/ml，t＝6.093]差值下降水平均高于对照组(P＜0.01)，IL-10[(6.23±1.79)pg/ml比(3.47±2.18)pg/ml，t＝5.359]差值升高水平高于对照组(P＜0.01)。治疗组胃肠不良反应发生率[10.0%(3/30)比36.7%(11/30)，χ2＝4.565]和肝功异常发生率[6.7%(2/30)比30.0%(9/30)，χ2＝4.007]均少于对照组(P＜0.01)。结论 复方鱼腥草合剂联合阿奇霉素干混悬剂可明显改善MRMPP患儿症状、体征，缩短病程，提高临床疗效。
- Abstract:
- Objective To observe the clinical effect of the Compound herba houttuyniae mixture combined with azithromycin for the children with macrolide-resistant mycoplasma pneumoniae(MRMPP) and investigate the bi-directional control mechanism of inflammatory response. Methods A total of 60 patients with MRMPP were randomly divided into control group and observation group of 30 patients each by random number table. Patients in control group took azithromycin, while patients in observation group took azithromycin and compound herba houttuyniae mixture. Both groups were treated 21 days. Results The total effective rate of observation group was 86.67%, while the control group was 56.67%, and the difference was statistical significance (χ2=5.253, P=0.022). The duration of fever (1.2 ± 0.3 d vs. 3.7 ± 2.2 d, t=6.293), cough (7.5 ± 2.3 d vs. 14.9 ± 3.7 d, t=9.232) in the observation group were significantly better than those in the control group (P<0.01). The serum concentrations of IL-6 (14.69 ± 8.26 pg/ml vs. 8.41 ± 5.26 pg/ml, t=3.512), IL-10 (6.23 ± 1.79 pg/ml vs. 3.47 ± 2.18 pg/ml, t=5.359), IL-17 (5.61 ± 2.77 pg/m vs. 2.09 ± 1.53 pg/ml, t=6.093) in the observation group were significantly decreased than the control group (P<0.01). There were fewer cases of gastrointestinal adverse events in the treatment group than in the control group (3 vs. 11 cases; χ2=4.565, P<0.05) and the number of abnormal liver function (2 vs. 9 cases; χ2=4.007, P<0.05). Conclusions Compound herba houttuyniae mixture combined with azithromycin could improve the clinical symptoms and signs, and shorten the symptoms duration and reduce the side reaction.
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备注/Memo
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更新日期/Last Update:
2018-08-06