Xie Shanshan*,Chen Yaqing,Ning Zhengyuan,et al.The effect of Shaoyao-Gancao grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone [J].,2016,38(09):790-792.[doi:10.3760/cma.j.issn.1673-4246.2016.09.007]
芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响
- Title:
- The effect of Shaoyao-Gancao grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone
- Keywords:
- Schizophrenia; Hyperprolactinemia; Risperidone; Shaoyao-Gancao grain; Prolactin; Positive and negative syndrome scale
- 摘要:
- 目的 探讨芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响。方法 将符合入选标准的100例女性精神分裂症患者采用随机数字表法分为2组，每组50例。对照组口服利培酮治疗，观察组在对照组基础上联用芍药甘草颗粒。2组均治疗12周。采用免疫化学发光法检测血清催乳素、雌激素水平，采用阳性及阴性症状量表(Positive and Negative Syndrome Scale, PANSS)评价患者的精神症状。结果 治疗后，观察组血清催乳素[(46.28±14.06)ng/ml比(117.89±22.11)ng/ml，t＝10.242]水平明显低于对照组(P＜0.01)。观察组治疗后PANSS评分[(67.45±7.00)分比(96.53±11.88)分，t＝7.125]、对照组PANSS评分[(68.73±7.71)分比(97.93±12.65)分，t＝6.541]均较同组治疗前降低(P＜0.01)，但2组治疗后比较，差异均无统计学意义(t＝0.682，P＞0.05)。结论 芍药甘草颗粒可降低利培酮所致的精神分裂症高催乳素血症患者的血清催乳素水平，且不影响其体内雌激素水平。
- Abstract:
- Objective To study the effect of Shaoyao Gancao Grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone. Methods 100 patients were randomly divided into the control group 50 cases，which were given risperidone. The study group 50 cases，which were given Shaoyao Gancao Grain on the basis of the control group. The two groups were treated for 12 weeks. Positive And Negative Syndrome Scale，serum prolactin and Estrogen level were measured by immunohistochemistry before and after 12 weeks of treatenmt. Results After 12 weeks of treatenmt，serum prolactin levels were decreased in the study group than control group (46.28 ± 14.06 ng/ml vs. 117.89 ± 22.11 ng/ml; t=10.242, P<0.01). PANSS score were decreased in the study group copare with before treatenmt (67.45 ± 7.00 vs. 96.53 ± 11.88; t=7.125, P<0.01). PANSS score were decreased in the control group copare with before treatenmt (68.73 ± 7.71 vs. 9 7.93 ± 12.65; t=6.541, P<0.01). But there were no difference in PANSS score between the two groups after treatenmt (t=0.682, P>0.05). Conclusions Shaoyao-Gancao grain can decrease serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone，does not affect estrogen levels.
参考文献/References:
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备注/Memo
通信作者：谢姗姗，Email: xlnln2014@163.com
更新日期/Last Update:
2016-09-06