Li Yuzhuo,Li Aizhen,Wang Jianmei,et al.Xiyanpingaerosol inhalation for pulmonary infection in patients with acute stroke [J].,2015,37(02):118-121.[doi:10.3760/cma.j.issn.1673-4246.2015.02.006]
喜炎平雾化吸入治疗急性脑卒中患者肺部感染的临床研究
- Title:
- Xiyanping aerosol inhalation for pulmonary infection in patients with acute stroke
- 摘要:
- 目的 探讨喜炎平雾化吸入治疗急性脑卒中患者肺部感染的疗效。方法 收集2011年2月-2013年3月急性脑卒中患者肺部感染者63例,按病历尾号将患者随机分为2组,对照组31例在常规治疗基础上配合抗感染、化痰药物治疗;治疗组32例在对照组治疗基础上,配合雾化吸入喜炎平治疗。2组均治疗7 d为1个疗程,共治疗2个疗程。比较患者症状、体征消失时间和炎性指标改化情况。结果 治疗组总有效率为93.75%(30/32),对照组为74.19%(23/31),2组比较差异有统计学意义(χ2=4.510,P=0.034)。治疗组咳嗽痰多[(5.94±1.25)d比(6.73±1.48)d;t=2.292,P=0.025]、发热[(2.72±0.11)d比(3.25±0.18)d;t=12.046,P=0.001]、肺部啰音[(5.22±1.15)d比(7.21±1.21)d;t=6.693,P=0.001]、呼吸困难[(1.17±0.49)d比(2.82±0.61)d;t=11.855,P=0.001]等症状、体征的消失时间均短于对照组。治疗组治疗后白细胞计数[(2.55±1.02)×109/L比(3.91±1.25)×109/L;t=4.738,P<0.01]、中性粒细胞比例[(4.92±1.32)%比(6.25±1.16)%;t=4.738,P<0.01]、淋巴细胞比例[(58.62±6.15)%比(65.94±6.17)%;t=4.716,P<0.01]均较对照组降低(P均<0.01)。结论 喜炎平雾化吸入可缩短急性脑卒中后肺部感染患者症状、体征时间,提高疗效。
- Abstract:
- Objective To investigate the therapeutic effectiveness of Xiyanping aerosol inhalation for pulmonary infection in patients with acute stroke. Methods Sixty-three patients with pulmonary infection after acute stroke were enrolled and randomly allocated to either a treatment group or a control group. The control group was treated with anti-infective and apophlegmatisant on the basis of standardized stroke treatment, the treatment group was treated with Xiyanping aerosol inhalation on the basis of the treatment in the control group. All patients were treated for 14 days. The resolution times of symptom and signs, and the changes of inflammatory parameters were compared. Results The total effective rate in the treatment group was significantly higher than that in the control group (93.75% vs. 74.19%; χ2=4.510, P=0.034). The resolution times of symptom and signs, such as cough and excessive phlegm (5.94 ± 1.25 d vs. 6.73 ± 1.48 d; t=2.292, P=0.025),fever (2.72 ± 0.11 d vs. 3.25 ± 0.18 d; t=12.046, P<0.01), pulmonary rale (5.22 ± 1.15 d vs. 7.21 ± 1.21 d; t=6.693, P<0.01), and dyspnea (1.17 ± 0.49 d vs. 2.82 ± 0.61 d; t=11.855, P<0.01) in the treatment group were significantly shorter than those in the control group. White blood cell count (2.55 ± 1.02 ×109/L vs. 3.91 ± 1.25 ×109/L; t=4.738, P<0.01), granulocyte proportion (4.92% ± 1.32% vs. 6.25% ± 1.16%; t=4.738, P<0.01) and lymphocyte proportion (58.62% ± 6.15% vs. 65.94% ± 6.17%; t=4.716, P<0.01) in the treatment group were significantly lower than those in the control group. Conclusions Xiyanping aerosol inhalation can shorten the resolution times of symptom and signs, and improve the therapeutic effectiveness in patients with pulmonary infection after acute stroke.
参考文献/References:
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更新日期/Last Update:
2015-02-02