脑出血后胰岛素样生长因子-1表达与中风闭、脱证关系的研究

Title:

Study on relationship among expression of IGF-1 in peri-hematomal brain region, excessive and depletion syndrome of stroke after cerebral hemorrhage

作者:

高丽丽 吴成翰

350003 福州，福建中医药大学附属第二人民医院神经内科

Author(s):

GAO Li-li;  WU Cheng-han

Department of Neurology, Second Clinical Academy of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China

关键词:

脑出血; 胰岛素样生长因子-1; 闭证; 脱证

Keywords:

Cerebral hemorrhage; Insulin-like growth factor-1; Excessive syndrome; Depletion syndrome

DOI:

10.3760/cma.j.issn.1673-4246.2012.03.005

摘要:

目的 观察脑出血（intracerebral hemorrhage，ICH）患者血肿周围脑组织中胰岛素样生长因子-1（IGF-1）的表达与中风闭、脱证的关系。方法 28例脑出血患者根据辨证分为3组：阴闭组、阳闭组、脱证组，另选6例非正常死亡者3 h内获取的正常脑组织标本，采用免疫印迹法检测血肿边缘区IGF-1的表达，研究IGF-1的表达与中医闭、脱证的关系。结果 ICH患者血肿周围脑组织中IGF-1表达明显高于正常对照组（P＝0.00），阳闭、阴闭、脱证三组之间血肿周围组织IGF-1表达[分别为(0.696±0.111)、(1.151±0.185)、(1.697±0.108)]两两比较，差异均有统计学意义（P＜0.01）。结论 脑出血后脑组织中IGF-1表达量的高低可反映病情轻重。

Abstract:

Objective To observe the expression of IGF-1 in the peri-hematomal brain region of Intracerebral Hemorrhage(ICH) patients, and to investigate the relationship among IGF-1, excessive and depletion syndrome of stroke. Methods 28 patients were evenly and randomly recruited into 3groups: Yin excessive group, Yang excessive group and depletion group. Additional 6 persons of normal death within 3 hours were taken their brain tissue. The IGF-1 expression was detected with Western blotting method.The correlation among the expression of IGF-1, excessive and depletion syndromes were observed. Results The expression of IGF-1 in the peri-hematomal brain region of ICH patients significantly increased in comparison with the normal control group (P＝0.00). The expression of IGF-1 was significantly different among Yang excessive, Yin excessive and the depletion syndromes [(0.696±0.111)、(1.151±0.185)、(1.697±0.108), P＜0.01], with the expression of IGF-1 of depletion syndrome ranked the highest, followed by Yin excessive and Yang excessive syndrome. Conclusion The expression of IGF-1 could reflect the degree of brain impairment.