活血化瘀方治疗中心性渗出性脉络膜视网膜病变的临床研究

Title:

Clinical research on the treatment of central exudative chorioretinopathy with blood-activating and stasis-removing Chinese medicines

作者:

葛建杰 高夕宁 李彩萍 田霞

264400 文登，山东威海市文登中心医院眼科

Author(s):

GE Jian-jie;  GAO Xi-ning;  LI Cai-ping;  TIAN Xia

Weihai City, Shandong Wendeng Central Hospital, Weihai 264400, China

关键词:

中心性渗出性脉络膜视网膜病变; 中药; 活血化瘀

Keywords:

Central exudative chorioretinopathy; Chinese medicine; Promoting blood circulation and removing blood stasis

DOI:

10.3760/cma.j.issn.1673-4246.2010.01.010

文献标志码:

A

摘要:

目的 观察中药活血化瘀方对中心性渗出性脉络膜视网膜病变(central exudative chorioretinopathy，CEC)的临床疗效。方法 将中心性渗出性脉络膜视网膜炎患者339例346眼，完全随机分为治疗组176例181眼和对照组163例165眼，治疗组采用中药辩证与辩病相结合的方法治疗，对照组采用常规疗法治疗。结果 治疗组矫正视力0.01～1.2，176例181眼中治愈76眼（41.99%）、好转85眼（46.96%）、无效20眼（11.05%），总有效率为88.95%。对照组163例165眼中治愈62眼（37.57%）、好转67眼（40.60%）、无效36眼（21.82%），总有效率为78.18%，两组总有效率比较差异有统计学意义（U＝2.05693，P＜0.05），治疗组治疗后3月进行FFA、OCT复查，治疗组中76眼荧光素渗漏消失、OCT示脉络膜新生血管(choroid al neovascularisation，CNV)病灶萎缩消失；85眼荧光素渗漏减轻、OCT示CNV病灶变小；12眼荧光素仍渗漏，8眼有瘢痕形成。结论 中药活血化瘀方可有效的促进眼底出血、渗出及视网膜水肿的消退，提高视力。

Abstract:

Objective To observe the effects of central exudative chorioretinopathy(central exudative chorioretinopathy, CEC) treated with blood-activating and stasis-removing Chinese medicines. Methods All 339 cases of central exudative chorioretinopathy with 346 infected eyes were randomly recruited into a treatment group (176 cases with 181 infected eyes) and a control group(163 cases with 165 infected eyes). The treatment group was treated with traditional Chinese medicine by dialectical combination of syndrome and disease, while the control group was treated with conventional treatment. Results The corrected visual acuity was 0.01～1.2 in the treatment group. Of all 181 eyes in 176 patients, 76 eyes were cured(41.98%), 85 eyes were improved(46.96%), and 20 eyes were ineffective(11.6%), with a total effective rate being 88.94%. By contrast, in the control group, of all 165 eyes in 163 patients, 62 eyes were cured(37.57%), 67 eyes were improved(40.60%), and 36 eyes were ineffective(21.83%), with a total effective rate being 78.17%. There was significant difference in the total effective difference between the two groups(U＝2.05693, P＜0.05). FFA and OCT were reexamined for the patients in the treatment group three months after the treatment. The results showed that fluorescein leakage and choroidal neovascularization(choroid al neovascularisation, CNV)lesions disappeared in 76 eyes; fluorescein leakage and CNV lesions relieved in 85 Eyes; fluorescein leakage still existed in 12 eyes; and scar formed in 8 eyes. Conclusion Blood-circulating and stasis-removing Chinese medicines have good effects in promoting subhyaloid hemorrhage and exudation, eliminating retinal oedema, and improving eyesight.