[1]李春芳 栗春敏 杨红欣 代贵江.参芪地黄汤对糖尿病大鼠肾功能作用的实验研究[J].国际中医中药杂志,2009,31(04):293-294.[doi:10.3760/cma.j.issn.1673-4246.2009.04.001]
　LI Chun-fang,LI Chun-min,YANG Hong-xin,et al.Experimental Study on Protective Function of Shenqi Dihuang Decoction on Diabetic Rats’ Kidney[J].,2009,31(04):293-294.[doi:10.3760/cma.j.issn.1673-4246.2009.04.001]
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参芪地黄汤对糖尿病大鼠肾功能作用的实验研究

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R] 卷: 31 期数: 2009年04期 页码: 293-294 栏目: 实验研究 出版日期: 2009-07-30
Title:
Experimental Study on Protective Function of Shenqi Dihuang Decoction on Diabetic Rats’ Kidney
作者:
李春芳 栗春敏 杨红欣 代贵江
157009 牡丹江，牡丹江医学院第二附属医院药剂科（李春芳、代贵江）；儿科（栗春敏、杨红欣）
Author(s):
LI Chun-fang;  LI Chun-min;  YANG Hong-xin;  DAI Gui-jiang.
The 2nd Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157009, China
关键词:
参芪地黄汤; 糖尿病肾病; 血管紧张素Ⅱ; 内皮素; 转化生长因子β1
Keywords:
Shenqi Dihuang decoction; Diabetic nephropathy; Ang-Ⅱendothelin; Transforming growth factor β1
DOI:
10.3760/cma.j.issn.1673-4246.2009.04.001
摘要:
目的 探讨参芪地黄汤对2型糖尿病大鼠肾脏的保护作用及其机制。方法 以低剂量链脲佐菌素（STZ）注射，制作2型糖尿病动物模型。将SD大鼠分为对照组、模型组和治疗组，治疗组用参芪地黄汤灌胃；对照组及模型组给予同等剂量的饮用水。24周后进行肾脏形态学和生化指标的检测，用放免法检测血清血管紧张素Ⅱ（Ang-Ⅱ）、血清和肾组织内皮素（ET）的水平；用免疫组织化学方法测量肾组织局部转化生长因子?1（TGF-?1）的表达。结果 与模型组比较，治疗组大鼠的肾功能及肾脏病变明显改善；血清Ang-Ⅱ、血清和肾组织ET水平降低；肾组织局部TGF-?1表达减少。结论 参芪地黄汤对2型糖尿病大鼠的肾脏有保护作用，其机制可能与降低血清Ang-Ⅱ、ET、肾组织ET和TGF-?1水平有关。
Abstract:
Objective To study the protective function and the mechanism of Shenqi Dihuang decoction on the kidney of type 2 diabetes mellitus rats. Methods Type 2 diabetes mellitus rat models were set up by injection of small dose of streptozotocin(STZ). The SD rats were randomized into a control group, a model group and a treatment group. The treatment group was given Shenqi Dihuang decoction. The control group and the model group were given the same amount of water. After 24 weeks, renal morphology examination and biochemical indicator were examined. The levels of Ang-Ⅱ and endothelin(ET)in serum were tested by radioimmunoassay and the level of transforming growth factor?1（TGF-?1）in renal cortex were determined by immunohistochemistry. Results The kidney function and kidney lesions were significantly improved in the treatment group than in the model group. Ang-ⅡAnd ET levels in serum and renal cortex was reduced, and the expression of TGF-?1 in the treatment group was decreased. Conclusion Shenqi Dihuang Decoction has protective effect on the kidney of diabetic rats, the mechanism may be related to its inhibition on the over expression of Ang-Ⅱ, ET and TGF-?1.

参考文献/References:

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［3］ 贺石林，王文健，王净净. 中医科研设计与统汁学. 长沙：湖南科学技术出版社，2001.
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