Su Qiuju,Yu Yan,Xing Jianwei.Clinical efficacy of Huxiang-Yangwei powder combined with conventional western medicine on gastric motility and gastrointestinal hormones in patients with chronic atrophic gastritis[J].,2019,41(7):692-696.[doi:10.3760/cma.j.issn.1673-4246.2019.07.005]
斛香养胃脐贴结合西医常规疗法对慢性萎缩性胃炎患者胃动力与胃肠道激素的影响
- Title:
- Clinical efficacy of Huxiang-Yangwei powder combined with conventional western medicine on gastric motility and gastrointestinal hormones in patients with chronic atrophic gastritis
- Keywords:
- Gastritis; atrophic; Huxiang-Yangwei powder; Gastric emptying; Prokinetic drugs (TCD); Motilin; Plastering therapy
- 摘要:
- 目的 探讨斛香养胃脐贴结合西医常规疗法对慢性萎缩性胃炎(chronic atrophic gastritis, CAG)患者胃动力与胃肠道激素的影响。方法 将符合入选标准的100例CAG患者按照随机数字表法分为2组，每组50例。对照组给予西医常规对症治疗，观察组在对照组基础上给予斛香养胃脐贴治疗。2组均治疗1个月。分析比较患者胃镜下评分、病理组织评分、胃动力指标(胃运动节律、胃电节律及胃窦动力)及胃肠激素(促胃动素、促胃液素、生长抑素)水平的变化，评价临床疗效。结果 观察组总有效率为92.0%(42/50)、对照组为78.0%(39/50)，2组比较差异有统计学意义(Z＝-2.978，P＝0.003)；治疗后，观察组胃镜下评分[(0.59±0.06)分比(1.23±0.17)分，t＝4.877]、病理组织评分[(0.65±0.08)分比(1.33±0.19)分，t＝5.096]均低于对照组(P＜0.05)；胃运动节律[(76.15±8.77)%比(62.35±7.31)%，t＝5.301]、胃电节律[(81.02±9.23)%比(73.02±8.43)%，t＝5.286]、胃窦动力[(0.012±0.002)Ω比(0.008±0.001)Ω，t＝4.160]均高于对照组(P＜0.05)；血浆促胃动素[(246.73±31.82)pg/ml比(203.86±27.91)pg/ml，t＝5.832]、促胃液素[(49.55±6.25)pg/ml比(35.81±4.63)pg/ml，t＝5.126]、生长抑素[(19.35±2.76)pg/ml比(15.01±2.60)pg/ml，t＝4.970]水平均高于对照组(P＜0.05)。结论 斛香养胃脐贴结合西医常规疗法有助于调节CAG患者胃肠激素水平，增加胃动力，修复胃黏膜。
- Abstract:
- Objective To observe clinical effect of Huxiang-Yangwei powder combined with conventional western medicine on gastric motility and gastrointestinal hormones in patients with chronic atrophic gastritis. Methods A total of 100 patients with chronic atrophic gastritis according to the inclusion criteria were randomly divided into the observation group and the control group, with 50 cases in each group. The control group was given routine symptomatic treatment. Based on the treatment of control group, the observation group was given Huxiang-Yangwei powder therapy. After 1 month, the gastroscope score, pathological tissue score, gastric motility index (gastric motility rhythm, gastroelectric rhythm and gastric antrum motility), and the improvement of plasma gastrointestinal hormone (MTL, GAS, SS) were compared. Results The total effective rate of the observation group was 92.0% (42/50), and the total effective rate of the control group was 78.0% (39/50), with statistically significant (Z=-2.978, P=0.003). After treatment, the under gastroscope score (0.59 ± 0.06 vs. 1.23 ± 0.17, t=4.877) and the pathological organization score (0.65 ± 0.08 vs. 1.33 ± 0.19, t=5.096) of the observation group were significantly lower than those of the control group (P<0.05). After treatment, the gastric motility rhythm (76.15% ± 8.77% vs. 62.35% ± 7.31%, t=5.301), gastroelectric rhythm (81.02% ± 9.23% vs. 73.02% ± 8.43%, t=5.286), gastric antral motility (0.012 ± 0.002 Ω vs. 0.008 ± 0.001 Ω, t=4.160) of the observation group were significantly higher than those of the control group (P<0.05). After treatment, the plasma MTL (246.73 ± 31.82 pg/ml vs. 203.86 ± 27.91 pg/ml, t=5.832), GAS (49.55 ± 6.25 pg/ml vs. 35.81 ± 4.63 pg/ml, t=5.126), SS (17.35 ± 2.76 pg/ml vs. 15.01 ± 2.60 pg/ml, t=4.970) of the observation group were significantly higher than those of the control group (P<0.05). Conclusions The application of Huxiang-Yangwei powder in the treatment of chronic atrophic gastritis patients can repair gastric mucosa, regulate gastrointestinal hormone levels and increase gastric motility.
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更新日期/Last Update:
2019-07-08