抗病毒中药阴道灌洗用于宫颈13种高危型人乳头瘤病毒感染的研究

Title:

Clinical research on Chinese herbs in the treatment of cervical HR-HPV infection

作者:

贾沄

511495 广州中医药大学祈福医院妇产科

Author(s):

JIA Yun

Clifford hospital Guangdong Province, Guangzhou 511495, China

关键词:

中药; 爱宝疗栓; 宫颈高危型人乳头瘤病毒

Keywords:

Antiviral herbs; Policresulen vaginal suppositories; 13 types of cervical HR-HPV

DOI:

10.3760/cma.j.issn.1673-4246.2013.05.005

摘要:

目的 探讨紫草、败酱草等中药采用水煎剂经阴道灌洗治疗宫颈高危型人乳头状瘤病毒（HR-HPV）感染的临床疗效。方法 选择祈福医院妇产科就诊的宫颈13种HR-HPV感染患者42例，宫颈液基薄层细胞学技术TCT提示CINI以内，根据患者是否自愿接受服用中药汤剂分为治疗组27例、对照组15例，治疗组应用中药汤剂治疗，对照组应用爱宝疗栓治疗，两组均治疗3个疗程（每月治疗7 d为1个疗程），比较对宫颈HR-HPV清除率及负荷量的影响。结果 治疗组HR-HPV转阴率88.5%、总有效率100%；对照组HR-HPV转阴率15.4%、总有效率46.2%。两组疗效比较差异有统计学意义（χ2＝17.062，P＜0.01）。结论 中药治疗宫颈HR-HPV感染效果肯定，未出现不良反应。

Abstract:

Objective To research the treatment of cervical HR-HPV infection by vaginal douching with eight kinds of antiviral herbs such as Radix Arnebiae and patrinia. Methods 42 patients with 13 types of cervical HR-HPV infection were selected from Outpatient. 27 patients were recruited into a treatment group and 15 patients were recruited into a control group voluntarily. The treatment group was applied with antiviral herbs and the control group was applied with policresulen vaginal suppositories for 3 courses (one course for 7 days per month). The clearance rate and loading dose of 13 types of cervical HR-HPV were observed. Results The negative conversion ratio of the treatment group and the control group was 88.5% and 15.4% respectively, and the total efficiency was 100% and 46.2% in the treatment group and the control group respectively. The total efficiency between the two groups were significantly different(χ2＝17.062, P＜0.01). Conclusion The therapeutic effect of antiviral herbs for cervical HR-HPV infection was definite and with no side reactions.