[1]李莉 咸玉欣 庄敏.参芪地黄汤联合二甲双胍治疗糖尿病肾病27例的疗效观察[J].国际中医中药杂志,2011,33(03):200-202.[doi:10.3760/cma.j.issn.1673-4246.2011.03.003]
　LI Li,XIAN Yu-xin,ZHUANG Min.Efficacy analysis on the treatment of diabetic nephropathy with Shengqidihuang decoction combined with metformin[J].,2011,33(03):200-202.[doi:10.3760/cma.j.issn.1673-4246.2011.03.003]
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参芪地黄汤联合二甲双胍治疗糖尿病肾病27例的疗效观察

《国际中医中药杂志》[ISSN:1673-4246/CN:CN11-5398/R] 卷: 33 期数: 2011年03期 页码: 200-202 栏目: 临床研究 出版日期: 2011-03-30
Title:
Efficacy analysis on the treatment of diabetic nephropathy with Shengqidihuang decoction combined with metformin
作者:
李莉 咸玉欣 庄敏
266000 山东省青岛大学医学院附属医院东区内科
Author(s):
LI Li;  XIAN Yu-xin;  ZHUANG Min
East area Medicine, the affiliated hospital of medical college Qingdao university, Qingdao 266000, China
关键词:
糖尿病肾病; 参芪地黄汤; 二甲双胍
Keywords:
Diabetic nephropathy; Shengqidihuang decoction; Metformin
DOI:
10.3760/cma.j.issn.1673-4246.2011.03.003
文献标志码:
A
摘要:
目的 观察参芪地黄汤联合二甲双胍治疗糖尿病肾病的临床疗效。方法 54例糖尿病肾病患者按照随机数字表法分为两组各27例，两组患者均进行糖尿病常规治疗。对照组在糖尿病常规治疗的基础上口服二甲双胍0.25 mg/次，3次/d，连服8周；治疗组在对照组的基础上加服参芪地黄汤加减治疗，1剂/d，4周为1个疗程，治疗2个疗程，两组患者均于治疗前后分别检测24小时尿蛋白定量（24 hUAE）、血清肌酐（SCr）、血尿素氮（BUN）、空腹血糖（FBG），并行疗效评定。结果 治疗组总有效率为85.2%，对照组为66.7%，两组总有效率比较，差异有统计学意义（χ2＝3.376，P＜0.05）；治疗组24 h UAE、SCr、BUN、FBG与对照组治疗后以及与同组治疗前组比较，差异均有统计学意义（χ2分别为4.231、3.754，P均＜0.05）。结论 采用参芪地黄汤联合二甲双胍治疗糖尿病肾病，疗效优于单纯用二甲双胍治疗。
Abstract:
Objective To observe the clinical effect of treating diabetic nephropathy with Shengqidihuang decoction combined with metformin. Methods 54 cases with diabetic nephropathy were randomly divided into two groups by means of random number table. Both groups were given diabetic routine treatment. The control group was treated with metformin, 0.25 mg each time, three times a day, based on the diabetic routine treatment for 8 weeks, and the treatment group was treated with Shengqidihuang decoction, once a day, 4 weeks as a course, continuously treated for 2 courses based on the control group. 24 h urinary protein（24hUAE）, serum creatinine（SCr）, blood urea nitrogen（BUN） and fasting blood glucose（FBG）were detected before and after the treatment. The clinical effect was observed between the two groups after the treatment. Results The total effective rate of the treatment group and the control group was 85.2% and 66.7% respectively, showing a significant difference (χ2＝3.376, P＜0.05). Compared with the control group, 24hUAE, SCr, BUN and FBG in the treatment group decreased significantly (χ2＝4.231, P＜0.05) after the treatment. 24hUAE, SCr, BUN and FBG decreased significantly after the treatment, especially in the treatment group, also showing a significant difference (χ2＝3.754, P＜0.05). Conclusion The therapy of metformin combined with Shengqidihuang decoction on diabetic nephropathy was better than metformin only.

参考文献/References:

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