小茴香挥发油对术后腹腔黏连的预防作用探讨

Title:

Study on preventive effect of volatile oil extracted from Foeniculum vulgare Mill. Seeds on postoperative intra-abdominal adhesions

作者:

滕光寿 王成果 毛峰峰 张琰 刘兴友 杨鹏 石磊 刘曼玲

710038 西安，第四军医大学唐都医院药剂科（滕光寿、张琰、刘兴友、杨鹏、石磊）；710032西安，第四军医大学唐都医院普外科（王成果），实验动物中心（毛峰峰），病理生理教研室（刘曼玲）

Author(s):

TENG Guang-shou*;  WANG Cheng-guo;  MAO Feng-feng;  ZHANG Yan;  LIU Xing-you;  YANG Peng;  SHI Lei;  LIU Man-ling

*Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

关键词:

小茴香; 挥发油; 腹腔黏连

Keywords:

Foeniculum vulgare Mill.Seeds; Volatile oil; Abdominal adhesion

DOI:

10.3760/cma.j.issn.1673-4246.2011.02.008

文献标志码:

A

摘要:

目的 探讨小茴香挥发油对术后腹腔黏连的预防作用。方法 将38只雄性SD大鼠按随机数字表法分为假手术组（10只）、手术对照组（14只）及小茴香挥发油组（14只）。假手术组只开腹，后两组开腹后无菌干纱布摩擦大鼠盲肠蚓突部，以钳夹和刮伤腹壁法制作大鼠腹腔黏连动物模型。各组于术后第7 d、14 d各处死一半动物，参考Phillips 5级分类法并结合本模型特点进行大体黏连程度分级评分。结果 小茴香挥发油组第7 d、14 d大体黏连程度评分均明显低于手术对照组，差异有统计学意义（P＜0.01）。结论 小茴香挥发油可预防大鼠腹腔黏连形成。

Abstract:

Objective To study the preventive effect of volatile oil extracted from Foeniculum vulgare Mill. Seeds on the formation of postoperative intra-abdominal adhesion. Methods Thirty-eihgt SD rats were randomly divided into sham operation group (10), operation group (14) and volatile oil treated group (14): sham operation group was only operated by abdominal incision, the rest two groups were established animal model of abdominal adhesion by rubbing the procussus vermiformis of cecum with dry sterile gauze, clamping and scuffing abdominal wall. Half of rats were separately killed on day 7 and day 14 after surgery, respectively. The degree of adhesion was evaluated according to Phillips 5-scale grade and the feature of this mode1. Results The scores of intra-abdominal adhesion were significantly lower in the carbachol group than those in operation group both on 7 d and 14 d（P＜0.01）. Conclusion Volatile oil extracted from Foeniculum vulgare Mill. Seeds may take a significant role in the prevention of postoperative abdominal adhesion in rats.